Ocular Colobomata

Ocular colobomata present diagnostic and therapeutic challenges in patients of all ages, but especially in young children. The “typical” coloboma, caused by defective closure of the fetal fissure, is located in the inferonasal quadrant, and it may affect any part of the globe traversed by the fissur...

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Veröffentlicht in:Survey of ophthalmology 2000-11, Vol.45 (3), p.175-194
Hauptverfasser: Onwochei, Benjamin C, Simon, John W, Bateman, J.Bronwyn, Couture, Kimberly C, Mir, Envar
Format: Artikel
Sprache:eng
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Zusammenfassung:Ocular colobomata present diagnostic and therapeutic challenges in patients of all ages, but especially in young children. The “typical” coloboma, caused by defective closure of the fetal fissure, is located in the inferonasal quadrant, and it may affect any part of the globe traversed by the fissure from the iris to the optic nerve. Ocular colobomata are often associated with microphthalmia, and they may be idiopathic or associated with various syndromes. Types and severity of complications vary depending on the location and size of the colobomata. This article reviews the pathogeneses, categorization, genetic bases, differential diagnoses and management of ocular coloboma.
ISSN:0039-6257
1879-3304
DOI:10.1016/S0039-6257(00)00151-X