A comparison of signal sequence prediction methods using a test set of signal peptides

We describe the creation of a test set containing secretory and non-secretory proteins. Five existing prediction programs for signal sequences and their cleavage sites are compared on the basis of this test set: SPScan, SigCleave, SignalP V1.1, SignalP V2.0.b2-HMM and SignalP V2.0.b2-NN. Availabilit...

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Veröffentlicht in:	Bioinformatics 2000-08, Vol.16 (8), p.741-742
Hauptverfasser:	Menne, Kerstin M.L., Hermjakob, Henning, Apweiler, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) non-secretory proteins Protein Sorting Signals secretory proteins Software
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Beschreibung
Zusammenfassung:	We describe the creation of a test set containing secretory and non-secretory proteins. Five existing prediction programs for signal sequences and their cleavage sites are compared on the basis of this test set: SPScan, SigCleave, SignalP V1.1, SignalP V2.0.b2-HMM and SignalP V2.0.b2-NN. Availability: Detailed results, the test set and the script to create the test set are available at ftp://ftp.ebi.ac.uk/pub/contrib/swissprot/testsets/signal/ Contact: hhe@ebi.ac.uk
ISSN:	1367-4803 1460-2059 1367-4811
DOI:	10.1093/bioinformatics/16.8.741