Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D: II. Structure Elucidation
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was...
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Veröffentlicht in: | Journal of antibiotics 2000/09/25, Vol.53(9), pp.873-878 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement. |
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ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.53.873 |