Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D: II. Structure Elucidation

The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was...

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Veröffentlicht in:Journal of antibiotics 2000/09/25, Vol.53(9), pp.873-878
Hauptverfasser: ISHIYAMA, DAISUKE, KANAI, YOSHINORI, SENDA, HISATO, IWATANI, WAKAO, TAKAHASHI, HIROKO, KONNO, HIROSHI, KANAZAWA, SUSUMU
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Sprache:eng
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Zusammenfassung:The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1, 4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.873