Feigrisolides A, B, C and D, New Lactones with Antibacterial Activities from Streptomyces griseus

Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feig...

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Veröffentlicht in:	Journal of antibiotics 2000/09/25, Vol.53(9), pp.934-943
Hauptverfasser:	TANG, YUAN-QING, SATTLER, ISABEL, THIERICKE, RALF, GRABLEY, SUSANNE, FENG, XIAO-ZHANG
Format:	Artikel
Sprache:	eng
Schlagworte:	3^a-Hydroxysteroid dehydrogenase 3a-Hydroxysteroid dehydrogenase Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Applied microbiology Bacillus subtilis - drug effects Bacillus subtilis - enzymology Biological and medical sciences Drug Screening Assays, Antitumor Enterovirus B, Human - drug effects feigrisolides Fundamental and applied biological sciences. Psychology HeLa Cells Humans Hydroxysteroid Dehydrogenases - antagonists & inhibitors K562 Cells lactones Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Microbiology Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Streptomyces griseus Streptomyces griseus - chemistry Streptomyces griseus - metabolism Xanthine Oxidase - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feigrisolide C (3) and D (4) are 16-membered macrodiolides. Biological studies showed that feigrisolide B (2) exhibited strong antibacterial, as well as medium cyctotoxic, and antiviral activities. Feigrisolides A (1), C (3) and D (4) are medium inhibitors of 3α-hydroxysteroid-dehydrogenase (3α-HSD) inhibiting activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.934