Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that t...

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Veröffentlicht in:	Neurology 2000-11, Vol.55 (9), p.1398-1401
Hauptverfasser:	WOULFE, J, HOOGENDOORN, H, TARNOPOLSKY, M, MUNOZ, D. G
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Antibodies, Monoclonal - immunology Biological and medical sciences Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme-Linked Immunosorbent Assay Herpesvirus 4, Human - immunology Humans Immunoblotting Immunohistochemistry Lewy Body Disease - pathology Medical sciences Nerve Tissue Proteins - immunology Neurology Parkinson Disease - immunology Parkinson Disease - pathology Synucleins
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Zusammenfassung:	Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with alpha-synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and alpha-synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.55.9.1398