cycloSaligenyl-5-[(E)-2-bromovinyl]-2′-deoxyuridine Monophosphate (cycloSal-BVDUMP) Pronucleotides Active against Epstein-Barr Virus

New potential nucleotide delivery systems directed against Epstein–Barr virus are represented by the 3′‐O‐acyl‐substituted 5′‐O‐cycloSaligenyl‐5‐[(E)‐2‐bromovinyl]‐2′‐deoxyuridine monophosphate (cycloSal‐BVDUMP) triesters 2 a–h, which are derivatives of the prototype triester 1. At least a few of th...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2001-04, Vol.2 (4), p.283-285
Hauptverfasser:	Meier, Chris, Lomp, Andreas, Meerbach, Astrid, Wutzler, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Bromodeoxyuridine - analogs & derivatives Bromodeoxyuridine - chemical synthesis Bromodeoxyuridine - chemistry Bromodeoxyuridine - pharmacology Cell Division - drug effects Deoxyuracil Nucleotides - chemical synthesis Deoxyuracil Nucleotides - pharmacology Epstein-Barr virus Herpesvirus 4, Human - drug effects Humans Hydrolysis nucleosides nucleotides prodrugs Structure-Activity Relationship Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	New potential nucleotide delivery systems directed against Epstein–Barr virus are represented by the 3′‐O‐acyl‐substituted 5′‐O‐cycloSaligenyl‐5‐[(E)‐2‐bromovinyl]‐2′‐deoxyuridine monophosphate (cycloSal‐BVDUMP) triesters 2 a–h, which are derivatives of the prototype triester 1. At least a few of these compounds showed promising antiviral activity in in vitro tests.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/1439-7633(20010401)2:4<283::AID-CBIC283>3.0.CO;2-V