A Novel β-Glucuronidase Inhibiting Triterpenoid from Paeonia emodi

A novel β-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi. Its structure has been established as 1β, 3β, 5α, 23, 24-pentahydroxy-30-norolean-12, 20(29)-dien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spec...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2000/11/01, Vol.48(11), pp.1771-1773
Hauptverfasser:	NAWAZ, Hafiz Rub, MALIK, Abdul, KHAN, Pir Muhammad, SHUJAAT, Shahida, RAHMAN, Atta-ur
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Asia Biological and medical sciences enzyme inhibition Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification General pharmacology Glucuronidase - antagonists & inhibitors Medical sciences Methylation Paeonia emodi Paeoniaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoid
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Beschreibung
Zusammenfassung:	A novel β-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi. Its structure has been established as 1β, 3β, 5α, 23, 24-pentahydroxy-30-norolean-12, 20(29)-dien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1, 5-dihydroxy-3-methyl-anthraquinone are also reported for the first time from Paeonia emodi.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.48.1771