A Case of Vesiculo‐Bullous Darier's Disease Associated with Bipolar Psychiatric Disorder

We describe the case of a 71‐year‐old men suffering from Darier's disease since his youth and presenting with intensely itching, vesicular and pustular lesions, localized on his arms, legs and on the ulnar side of his right hand. The patient also had a 30 year‐history of bipolar psychiaric diso...

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Veröffentlicht in:Journal of dermatology 2000-10, Vol.27 (10), p.673-676
Hauptverfasser: Mei, Sandra, Amato, Lauretta, Gallerani, Isabella, Perrella, Esterina, Caproni, Marzia, Palleschi, Giovanni Maria, Fabbri, Paolo
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container_end_page 676
container_issue 10
container_start_page 673
container_title Journal of dermatology
container_volume 27
creator Mei, Sandra
Amato, Lauretta
Gallerani, Isabella
Perrella, Esterina
Caproni, Marzia
Palleschi, Giovanni Maria
Fabbri, Paolo
description We describe the case of a 71‐year‐old men suffering from Darier's disease since his youth and presenting with intensely itching, vesicular and pustular lesions, localized on his arms, legs and on the ulnar side of his right hand. The patient also had a 30 year‐history of bipolar psychiaric disorders. The histopathological examination of lesional skin showed suprabasal acantholytic clefting, hyperparakeratosis, and dyskeratosis. Histopathological and immunopathological (direct and indirect immunofluorescence) results, were consistent with vesiculo‐bullous Darier's disease. Corticosteroid therapy with methylprednisolone at low dosage (0.2 mg/kg/day) was started with a quick resolution of the vesicular lesions on his arms and legs.
doi_str_mv 10.1111/j.1346-8138.2000.tb02252.x
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subjects Aged
Anti-Inflammatory Agents - therapeutic use
Bipolar Disorder - complications
bipolar psychiatric disorder
Darier Disease - complications
Darier Disease - diagnosis
Darier Disease - drug therapy
Darier Disease - pathology
Diagnosis, Differential
Extremities
Fluorescent Antibody Technique
Glucocorticoids - therapeutic use
Humans
Male
Methylprednisolone - therapeutic use
systemic corticosteroid therapy
vesiculo‐bullous Darier's disease
title A Case of Vesiculo‐Bullous Darier's Disease Associated with Bipolar Psychiatric Disorder
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