A Case of Vesiculo‐Bullous Darier's Disease Associated with Bipolar Psychiatric Disorder

We describe the case of a 71‐year‐old men suffering from Darier's disease since his youth and presenting with intensely itching, vesicular and pustular lesions, localized on his arms, legs and on the ulnar side of his right hand. The patient also had a 30 year‐history of bipolar psychiaric diso...

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Veröffentlicht in:Journal of dermatology 2000-10, Vol.27 (10), p.673-676
Hauptverfasser: Mei, Sandra, Amato, Lauretta, Gallerani, Isabella, Perrella, Esterina, Caproni, Marzia, Palleschi, Giovanni Maria, Fabbri, Paolo
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Sprache:eng
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Zusammenfassung:We describe the case of a 71‐year‐old men suffering from Darier's disease since his youth and presenting with intensely itching, vesicular and pustular lesions, localized on his arms, legs and on the ulnar side of his right hand. The patient also had a 30 year‐history of bipolar psychiaric disorders. The histopathological examination of lesional skin showed suprabasal acantholytic clefting, hyperparakeratosis, and dyskeratosis. Histopathological and immunopathological (direct and indirect immunofluorescence) results, were consistent with vesiculo‐bullous Darier's disease. Corticosteroid therapy with methylprednisolone at low dosage (0.2 mg/kg/day) was started with a quick resolution of the vesicular lesions on his arms and legs.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2000.tb02252.x