Germacranolides and a New Type of Guaianolide from Acanthospermum hispidum

The aerial parts of an Argentinian collection of Acanthospermum hispidum afforded 26 sesquiterpene lactones, including the two guaianolides (1 and 2) having a novel oxygen bridge between C-4 and C-14, three new cis,cis-germacranolides (4, 7, and 8), and two new melampolides (25 and 26). Guaianolides...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-10, Vol.63 (10), p.1323-1328
Hauptverfasser:	CARTAGENA, Elena, BARDóN, Alicia, CATALáN, César A. N., DE HERNáNDEZ, Zaida N. J., HERNáNDEZ, Luis R., JOSEPH-NATHAN, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Argentina Biological and medical sciences Esters - chemistry Esters - isolation & purification Furans - chemistry Furans - isolation & purification General pharmacology Lactones - chemistry Lactones - isolation & purification Magnetic Resonance Spectroscopy Magnoliopsida - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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Zusammenfassung:	The aerial parts of an Argentinian collection of Acanthospermum hispidum afforded 26 sesquiterpene lactones, including the two guaianolides (1 and 2) having a novel oxygen bridge between C-4 and C-14, three new cis,cis-germacranolides (4, 7, and 8), and two new melampolides (25 and 26). Guaianolides 1 and 2 seem to derive biosynthetically from the germacranolide 27 having the (1)D(14, 15)D(5) conformation. The structures were elucidated using extensive spectroscopic analysis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9905057