New Norditerpenoid Alkaloids from Aconitum falconeri
The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3‘-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plan...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2000-10, Vol.63 (10), p.1393-1395 |
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| container_end_page | 1395 |
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| container_issue | 10 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 63 |
| creator | Atta-ur-Rahman Fatima, Nuzhat Akhtar, Farzana Choudhary, M. Iqbal Khalid, Asaad |
| description | The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3‘-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plant. The previously reported pseudaconitine (3) was also isolated. Compounds 1 and 3 were found to be moderate inhibitors of the enzyme acetylcholinesterase. |
| doi_str_mv | 10.1021/np9905315 |
| format | Article |
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Iqbal</creatorcontrib><creatorcontrib>Khalid, Asaad</creatorcontrib><title>New Norditerpenoid Alkaloids from Aconitum falconeri</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3‘-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plant. The previously reported pseudaconitine (3) was also isolated. Compounds 1 and 3 were found to be moderate inhibitors of the enzyme acetylcholinesterase.</description><subject>Biological and medical sciences</subject><subject>Cholinesterase Inhibitors - chemistry</subject><subject>Cholinesterase Inhibitors - isolation & purification</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - isolation & purification</subject><subject>General pharmacology</subject><subject>Magnoliopsida - chemistry</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Plant Roots - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atta-ur-Rahman</creatorcontrib><creatorcontrib>Fatima, Nuzhat</creatorcontrib><creatorcontrib>Akhtar, Farzana</creatorcontrib><creatorcontrib>Choudhary, M. Iqbal</creatorcontrib><creatorcontrib>Khalid, Asaad</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atta-ur-Rahman</au><au>Fatima, Nuzhat</au><au>Akhtar, Farzana</au><au>Choudhary, M. 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| identifier | ISSN: 0163-3864 |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Diterpenes - chemistry Diterpenes - isolation & purification General pharmacology Magnoliopsida - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry |
| title | New Norditerpenoid Alkaloids from Aconitum falconeri |
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