New Norditerpenoid Alkaloids from Aconitum falconeri

The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3‘-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plan...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-10, Vol.63 (10), p.1393-1395
Hauptverfasser:	Atta-ur-Rahman, Fatima, Nuzhat, Akhtar, Farzana, Choudhary, M. Iqbal, Khalid, Asaad
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Diterpenes - chemistry Diterpenes - isolation & purification General pharmacology Magnoliopsida - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry
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Beschreibung
Zusammenfassung:	The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3‘-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plant. The previously reported pseudaconitine (3) was also isolated. Compounds 1 and 3 were found to be moderate inhibitors of the enzyme acetylcholinesterase.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9905315