Diheteropeptin, a Novel Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia: II. Physico-chemical Properties and Structure Elucidation

The structure of diheteropeptin (1), a TGF-β-like active substance from Diheterospora chlamydosporia Q58044, was determined to be a new cyclotetrapeptide, cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S, 8R, 9R)-2-amino-8, 9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies...

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Veröffentlicht in:	Journal of antibiotics 2000/08/25, Vol.53(8), pp.793-798
Hauptverfasser:	MASUOKA, YUHTA, SHIN-YA, KAZUO, FIMIHATA, KAZUO, MATSUMO, HISAO, TAKEBAYASHI, YUKIHIRO, NAGAI, KOJI, SUZUKI, KJEN-ICHI, HAYAKAWA, YOICHI, SETO, HARUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Circular Dichroism cyclopeptides Decanoic Acids - chemistry Decanoic Acids - metabolism Decanoic Acids - pharmacology diheteropeptin Diheterospora chlamydosporia Fundamental and applied biological sciences. Psychology Hypocreales - metabolism Magnetic Resonance Spectroscopy Microbiology Molecular Structure Stereoisomerism TGF-^b Transforming Growth Factor beta - pharmacology
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Zusammenfassung:	The structure of diheteropeptin (1), a TGF-β-like active substance from Diheterospora chlamydosporia Q58044, was determined to be a new cyclotetrapeptide, cyclo[2-aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S, 8R, 9R)-2-amino-8, 9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.793