Cytotoxic triterpenoides from Alismatis Rhizoma

Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation usingin vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amo...

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Veröffentlicht in:	Archives of pharmacal research 2001-12, Vol.24 (6), p.524-526
Hauptverfasser:	Lee, SangMyung, Kho, YungHee, Min, ByungSun, Kim, JinHee, Na, MinKyun, Kang, ShinJyung, Maeng, HackYoung, Bae, KiHwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cholestenones - isolation & purification Cholestenones - pharmacology cytotoxicity Humans methanol Mice Plants, Medicinal - chemistry spectroscopy triterpenoids Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation usingin vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED₅₀ values of 7.5, 7.5, 4.9 μg/ml, respectively.
ISSN:	0253-6269 1976-3786
DOI:	10.1007/bf02975158