The Effect of Selective Estrogen Receptor Modulators on Parameters of the Hypothalamic-Pituitary-Gonadal Axis

: The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic‐pituitary‐gonadal (HPG) axis has not been the primary focus of the...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2001-12, Vol.949 (1), p.251-258
Hauptverfasser:	PLOUFFE JR, LEO, SIDDHANTI, SURESH
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Follicle Stimulating Hormone - metabolism Gonads - drug effects Humans hypothalamic-pituitary-gonadal axis Hypothalamo-Hypophyseal System - drug effects Male males postmenopause Postmenopause - drug effects Postmenopause - physiology premenopause Premenopause - drug effects Premenopause - physiology selective estrogen receptor modulators Selective Estrogen Receptor Modulators - pharmacology
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Beschreibung
Zusammenfassung:	: The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic‐pituitary‐gonadal (HPG) axis has not been the primary focus of the studies conducted thus far. However the effect of SERMs on the HPG axis and the associated regulation of endocrine parameters may play an important role in their overall clinical profile. In this review the effects of selected SERMs on the HPG axis in premenopausal women, postmenopausal women, and men are summarized.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2001.tb04029.x