Diastereoselective Synthesis of 2H,5H-Dihydrofurans by Cobalt-Mediated Cycloisomerization of Allyl Propargyl Ethers. Application to Poly-THF Molecules

Diastereoselective Synthesis of 2H,5H-Dihydrofurans by Cobalt-Mediated Cycloisomerization of Allyl Propargyl Ethers. Application to Poly-THF Molecules

Allyl propargyl ethers undergo cobalt-mediated cycloisomerization reactions to form dihydrofurans in good yield and with excellent diastereoselectivity. The reaction works with a range of substrates, and its utility in synthesis is exemplified by the preparation of a bistetrahydrofuran unit.

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Veröffentlicht in:Organic letters 2001-12, Vol.3 (26), p.4161-4164
Hauptverfasser: Ajamian, Alain, Gleason, James L
Format: Artikel
Sprache:eng
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Zusammenfassung:Allyl propargyl ethers undergo cobalt-mediated cycloisomerization reactions to form dihydrofurans in good yield and with excellent diastereoselectivity. The reaction works with a range of substrates, and its utility in synthesis is exemplified by the preparation of a bistetrahydrofuran unit.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol016768l