Progesterone side-chain cleavage by Bacillus sphaericus

Progesterone side-chain cleavage by Bacillus sphaericus

Abstract The side-chain of progesterone was cleaved by Bacillus sphaericus to produce two C-19 keto androstene steroids. The structures of these metabolites were androstenedione and 1-dehydroandrostenedione. High concentrations of glucose in the culture medium inhibited conversion of progesterone to...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:FEMS microbiology letters 2000-11, Vol.192 (2), p.179-183
Hauptverfasser: Wadhwa, Lalita, Smith, Kelvin E
Format: Artikel
Sprache:eng
Schlagworte:
1-dehydroandrostenedione
Androstadienedione
Androstenedione
Androstenedione - analysis
Androstenedione - chemistry
Bacillus - metabolism
Bacillus sphaericus
Bacteriology
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Biotransformation
Chains
Chromatography, Thin Layer
Fundamental and applied biological sciences. Psychology
Glucose - pharmacology
Metabolism. Enzymes
Metabolites
Microbiology
Mission oriented research
Molecular Structure
Physiology and metabolism
Progesterone
Progesterone - metabolism
Steroid hormones
Steroid side‐chain cleavage
Steroids
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract The side-chain of progesterone was cleaved by Bacillus sphaericus to produce two C-19 keto androstene steroids. The structures of these metabolites were androstenedione and 1-dehydroandrostenedione. High concentrations of glucose in the culture medium inhibited conversion of progesterone to these two metabolites.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2000.tb09379.x