Pharmacokinetics of rectal paracetamol after repeated dosing in children

Twenty-three children(aged between 9 weeks and 11 yr) were given paracetamol suppositories 25 mgkg−1 every 6 h (maximum 5 days) after major surgery andserum and saliva concentrations were measured. There was a good correlation(r=0.91, P

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Bibliographische Detailangaben
Veröffentlicht in:	British Journal of Anaesthesia 2000-10, Vol.85 (4), p.512-519
Hauptverfasser:	Hahn, T.W., Henneberg, S.W., Holm-Knudsen, R.J., Eriksen, K., Rasmussen, S.N., Rasmussen, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - administration & dosage Acetaminophen - blood Acetaminophen - pharmacokinetics Administration, Rectal Analgesics analgesics non-opioid, paracetamol Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - blood Analgesics, Non-Narcotic - pharmacokinetics Anthropometry Biological and medical sciences Child Child, Preschool children Drug Administration Schedule Female Humans Infant Male Medical sciences Models, Biological Neuropharmacology Pain, Postoperative - blood Pain, Postoperative - prevention & control pharmacokinetics,paracetamol Pharmacology. Drug treatments Saliva - metabolism Suppositories
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Beschreibung
Zusammenfassung:	Twenty-three children(aged between 9 weeks and 11 yr) were given paracetamol suppositories 25 mgkg−1 every 6 h (maximum 5 days) after major surgery andserum and saliva concentrations were measured. There was a good correlation(r=0.91, P
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/85.4.512