Comparative evaluation of two hemagglutination tests for the detection of anti-Helicobacter pylori antibodies

Two hemagglutination assays (IHAs) for detecting anti-H. pylori antibodies were evaluated. In 257 patients, both tests revealed sensitivity or specificity values between 71-79% or 81-82%, respectively, which were lower than those of an anti-H. pylori ELISA. Notably, the sensitivities of both IHAs va...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2001-12, Vol.41 (4), p.221-223
Hauptverfasser:	NILIUS, Manfred, WEX, Thomas, MÜLLER-DIETZ, Gerhard, LEODOLTER, Andreas, SCHILLING, Dieter, MALFERTHEINER, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Animals Antibodies, Bacterial - analysis Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacteriological methods and techniques used in bacteriology Bacteriology Biological and medical sciences Enzyme-Linked Immunosorbent Assay - methods Fundamental and applied biological sciences. Psychology Helicobacter Infections - diagnosis Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter pylori - immunology Helicobacter pylori - isolation & purification Hemagglutination Tests - methods Human bacterial diseases Humans Infectious diseases Medical sciences Microbiology Middle Aged Reagent Kits, Diagnostic Sensitivity and Specificity Sheep
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Zusammenfassung:	Two hemagglutination assays (IHAs) for detecting anti-H. pylori antibodies were evaluated. In 257 patients, both tests revealed sensitivity or specificity values between 71-79% or 81-82%, respectively, which were lower than those of an anti-H. pylori ELISA. Notably, the sensitivities of both IHAs varied in subgroups of patients between 48-95%. Based on the validation, the IgG-ELISA is superior to both IHAs tested, and therefore, should be used in routine diagnostics.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/S0732-8893(01)00306-6