Effects of budesonide and prednisolone on hepatic kinetics for urea synthesis
Background/Aims: Glucocorticoids upregulate hepatic urea synthesis and cause protein breakdown to prevail over synthesis, releasing amino acids into the blood stream and increasing the substrate supply for hepatic urea synthesis. Budesonide is a new generation glucocorticoid that may be used for tre...
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Veröffentlicht in: | Journal of hepatology 2000-10, Vol.33 (4), p.549-554 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background/Aims: Glucocorticoids upregulate hepatic urea synthesis and cause protein breakdown to prevail over synthesis, releasing amino acids into the blood stream and increasing the substrate supply for hepatic urea synthesis. Budesonide is a new generation glucocorticoid that may be used for treatment of inflammatory diseases, e.g. Crohn's disease and autoimmune hepatitis. Due to its extensive first-pass metabolism in the liver, it has a potential adverse effect profile superior to that of prednisolone. Little attention has been directed towards differences in nitrogen catabolic properties between budesonide and prednisolone.
Methods: Eight normal male subjects (age 20–44 years; BMI 21.6–28.2 kg/m
2) were randomly studied 3 times: 1) At baseline, 2) after 6 days of prednisolone (50 mg/day), and 3) after 6 days of budesonide (9 mg/day). We measured urea nitrogen synthesis rates (UNSR) and blood α-amino-nitrogen (N) levels before, during, and after a 3-h constant infusion of alanine (2 mmol/(kg BW×h)). UNSR was estimated hourly as urinary excretion corrected for gut hydrolysis and accumulation in body water. The slope of the linear relationship between UNSR and amino-N concentration represents the hepatic kinetics of conversion of amino- to urea-N, and is denoted the functional hepatic nitrogen clearance (FHNC).
Results: Prenisolone, but not budesonide, administration increased basal blood and amino nitrogen concentrations (3.5±0.1 mmol/l (control)
vs 3.8±0.1 mmol/l (prednisolone) (
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ISSN: | 0168-8278 1600-0641 |
DOI: | 10.1016/S0168-8278(00)80006-9 |