Associations of Plasma Endothelin Concentration with Carotid Atherosclerosis and Asymptomatic Cerebrovascular Lesions in Patients with Essential Hypertension

We studied the association of endothelin (ET)-1 with carotid atherosclerosis and asymptomatic cerebrovascular lesions in patients with essential hypertension. Neurologically normal patients with essential hypertension (n=293; 138 male, 155 female; mean age, 65 years) and age-matched control subjects...

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Veröffentlicht in:	Hypertension Research 2001, Vol.24(6), pp.663-670
Hauptverfasser:	MINAMI, Shigetoshi, YAMANO, Shigeru, YAMAMOTO, Yuta, SASAKI, Rie, NAKASHIMA, Takao, TAKAOKA, Minoru, HASHIMOTO, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged asymptomatic lacune Carotid Artery Diseases - complications Carotid Artery Diseases - diagnostic imaging carotid plaque Cerebral Infarction - complications Cerebrovascular Disorders - complications Cerebrovascular Disorders - diagnosis endothelin-1 Endothelin-1 - blood essential hypertension Female Humans Hypertension - blood Hypertension - complications Intracranial Arteriosclerosis - complications Intracranial Arteriosclerosis - diagnostic imaging Magnetic Resonance Imaging Male Middle Aged Osmolar Concentration periventricular hyperintensity Reference Values Ultrasonography
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Zusammenfassung:	We studied the association of endothelin (ET)-1 with carotid atherosclerosis and asymptomatic cerebrovascular lesions in patients with essential hypertension. Neurologically normal patients with essential hypertension (n=293; 138 male, 155 female; mean age, 65 years) and age-matched control subjects (n=242) were studied with B-mode ultrasonography of the common and internal carotid arteries and magnetic resonance imaging of the brain. Plasma ET-1 was measured by enzyme immunoassay. Hypertensive patients were divided into groups with carotid plaques and low ET-1 concentrations (
ISSN:	0916-9636 1348-4214
DOI:	10.1291/hypres.24.663