Acquired Robertsonian translocations in two leukemia patients

Robertsonian translocations were observed in two leukemia patients. The first case was a patient with chronic lymphocytic leukemia, who was found to have a rare Robertsonian translocation der(14;15)(q10;q10). The second case, a patient with acute myeloid leukemia, had multiple Robertsonian transloca...

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Veröffentlicht in:	Cancer genetics and cytogenetics 2001-12, Vol.131 (2), p.104-108
Hauptverfasser:	Chinnappan, Dharmaraj, Philip, Abraham, Wu, Xiao, Pan, Agen, Wyandt, Herman E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Biological and medical sciences Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 15 Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Myeloid - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Translocation, Genetic
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Zusammenfassung:	Robertsonian translocations were observed in two leukemia patients. The first case was a patient with chronic lymphocytic leukemia, who was found to have a rare Robertsonian translocation der(14;15)(q10;q10). The second case, a patient with acute myeloid leukemia, had multiple Robertsonian translocations: der(15)t(13;15)(q11.1;p11.1), der(14;22)(q10;q10), and dic(21;22)(p11.1;p11.1). Acquired multiple Robertsonian translocations have not been reported previously in leukemia.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/S0165-4608(01)00478-2