Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo- l-Trp- l-Pro

The synthesis of three isoprenylated derivatives of cyclo- l-Trp- l-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2000-10, Vol.8 (10), p.2407-2415
Hauptverfasser:	Sanz-Cervera, Juan F, Stocking, Emily M, Usui, Takeo, Osada, Hiroyuki, Williams, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cattle Cells, Cultured - drug effects Fibroblasts - drug effects General aspects Indole Alkaloids Indoles - pharmacology Medical sciences Microtubule-Associated Proteins - analysis Microtubules - drug effects Mitosis - drug effects Molecular Structure Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Piperazines Protein Prenylation Rats
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Beschreibung
Zusammenfassung:	The synthesis of three isoprenylated derivatives of cyclo- l-Trp- l-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/S0968-0896(00)00171-1