Nonreceptor Tyrosine Phosphatases in Cellular Signaling: Regulation of Mitogen-Activated Protein Kinases

A large number of nonreceptor tyrosine phosphatases have been shown to specifically regulate mitogen-activated protein kinase (MAPK) signaling. Zhan, et al, provide an overview of MAPK signaling and then discuss the functions of intracellular PTPases, particularly the functions of PTPases in MAPK re...

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Veröffentlicht in:	Chemical reviews 2001-08, Vol.101 (8), p.2477-2496
Hauptverfasser:	Zhan, Xiao-Li, Wishart, Matthew J, Guan, Kun-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cells Mitogen-Activated Protein Kinases - metabolism Protein Tyrosine Phosphatases - metabolism Proteins Signal Transduction Substrate Specificity
Online-Zugang:	Volltext
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Zusammenfassung:	A large number of nonreceptor tyrosine phosphatases have been shown to specifically regulate mitogen-activated protein kinase (MAPK) signaling. Zhan, et al, provide an overview of MAPK signaling and then discuss the functions of intracellular PTPases, particularly the functions of PTPases in MAPK regulation.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr000245u