Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Leslie, et al., discuss recent research aimed at understanding the mechanism by which activation of PI 3-kinase, and hence formation of PtdIns(3,4,5)P(3), enables PDK1 to phosphoylate and activate a group of serine/threonine protein kinases that belong to the AGC subfamily of protein kinases. They a...

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Veröffentlicht in:Chemical reviews 2001-08, Vol.101 (8), p.2365-2380
Hauptverfasser: Leslie, Nick R, Biondi, Ricardo M, Alessi, Dario R
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Biochemistry
Cells
Phosphatidylinositols - metabolism
Phosphoprotein Phosphatases - metabolism
Phosphorylation
Protein Kinases - metabolism
Proteins
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Zusammenfassung:Leslie, et al., discuss recent research aimed at understanding the mechanism by which activation of PI 3-kinase, and hence formation of PtdIns(3,4,5)P(3), enables PDK1 to phosphoylate and activate a group of serine/threonine protein kinases that belong to the AGC subfamily of protein kinases. They also discuss the importance of the PTEN and the SHIP phosphoinositide phosphatases that play key roles in regulating the cellular concentration of PtdIns(3,4,5)P(3).
ISSN:0009-2665
1520-6890
DOI:10.1021/cr000091i