Glycogen Synthase Kinase-3:  Properties, Functions, and Regulation

Glycogen Synthase Kinase-3:  Properties, Functions, and Regulation

Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase encoded by two isoforms in mammals, termed GSK-3alpha and GSK-3beta. Ali, et al, discuss the biochemical and functional properties of GSK-3 and the recent advances in understanding of the involvement of this unusual enzyme in human path...

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Veröffentlicht in:Chemical reviews 2001-08, Vol.101 (8), p.2527-2540
Hauptverfasser: Ali, Adnan, Hoeflich, Klaus P, Woodgett, James R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemistry
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Chemicals
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Inflammation - enzymology
Mammals
Pathology
Proteins
Signal Transduction
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Zusammenfassung:Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase encoded by two isoforms in mammals, termed GSK-3alpha and GSK-3beta. Ali, et al, discuss the biochemical and functional properties of GSK-3 and the recent advances in understanding of the involvement of this unusual enzyme in human patho-physiology.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr000110o