Antiretroviral therapy of HIV-1 infection: established treatment strategies and new therapeutic options

Recently, studies have shown that non-nucleoside reverse transcriptase inhibitors, such as efavirenz or nevirapine, in combination with two nucleoside analogues have an antiretroviral potency comparable to protease inhibitor containing regimens. Triple combination therapy that includes a non-nucleos...

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Veröffentlicht in:	Current Opinion in Microbiology 2000-10, Vol.3 (5), p.508-514
Hauptverfasser:	Kaufmann, Gilbert R, Cooper, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active efavirenz HIV Infections - drug therapy HIV Protease Inhibitors - therapeutic use HIV-1 Human immunodeficiency virus 1 Humans nevirapine Reverse Transcriptase Inhibitors - therapeutic use Salvage Therapy
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Beschreibung
Zusammenfassung:	Recently, studies have shown that non-nucleoside reverse transcriptase inhibitors, such as efavirenz or nevirapine, in combination with two nucleoside analogues have an antiretroviral potency comparable to protease inhibitor containing regimens. Triple combination therapy that includes a non-nucleoside reverse transcriptase inhibitor can therefore be regarded as an effective alternative first-line treatment of HIV-1 infection.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/S1369-5274(00)00131-4