Similar expression and regulation of Gli2 and Gli3 in the chick limb bud

Gli genes encode a family of zinc finger transcription factors that mediate signaling by Hedgehog proteins. We have cloned the chick Gli3 gene and studied its expression in developing chick limbs. Gli3 expression is highly similar to that of chick Gli2. Gli3 mRNA is evenly distributed in the early l...

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Veröffentlicht in:	Mechanisms of development 2000-11, Vol.98 (1), p.171-174
Hauptverfasser:	Schweitzer, Ronen, Vogan, Kyle J, Tabin, Clifford J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chick Chick Embryo Cloning, Molecular DNA-Binding Proteins - genetics Extremities - embryology Gene Expression Regulation, Developmental Gli3 Hedgehog Proteins In Situ Hybridization Kruppel-Like Transcription Factors Limb Molecular Sequence Data Nerve Tissue Proteins Proteins - genetics Repressor Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid Signal Transduction Sonic hedgehog Trans-Activators Transcription Factors - genetics Xenopus Proteins Zinc Finger Protein Gli2 Zinc Finger Protein Gli3 Zinc Fingers - genetics
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Beschreibung
Zusammenfassung:	Gli genes encode a family of zinc finger transcription factors that mediate signaling by Hedgehog proteins. We have cloned the chick Gli3 gene and studied its expression in developing chick limbs. Gli3 expression is highly similar to that of chick Gli2. Gli3 mRNA is evenly distributed in the early limb mesenchyme and subsequently downregulated in the posterior mesenchyme by the polarizing activity of Sonic hedgehog. At later stages, Gli3 is expressed in the distal limb mesenchyme.
ISSN:	0925-4773 1872-6356
DOI:	10.1016/S0925-4773(00)00458-5