Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men

The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance. Genotyping for the C46T variant was performed in 2624 men 50 to 61 yea...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-10, Vol.102 (17), p.2058-2062
Hauptverfasser:	ZITO, Francesco, DRUMMOND, Felicity, BUJAC, Sarah R, ESNOUF, M. Peter, MORRISSEY, James H, HUMPHRIES, Steve E, MILLER, George J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers Cardiology. Vascular system Coronary Disease - diagnosis Coronary Disease - epidemiology Coronary Disease - genetics Coronary Disease - metabolism Coronary heart disease Factor VII - genetics Factor VII - metabolism Factor XIIa - genetics Factor XIIa - metabolism Fibrinopeptide A - genetics Fibrinopeptide A - metabolism Genetic Predisposition to Disease Genetic Testing Genotype Heart Humans Male Medical sciences Middle Aged Polymorphism, Genetic Prospective Studies Risk Factors
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Zusammenfassung:	The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance. Genotyping for the C46T variant was performed in 2624 men 50 to 61 years of age who were free of CHD at baseline. The genotype distribution was as follows: CC, 56.7%; CT; 36.9%; and TT, 6.6%. Plasma FXIIa was measured by ELISA on 1745 samples collected 1 year after baseline; median levels were (ng/mL) CC, 2.0; CT, 1.4; and TT, 0.8 (P:
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.102.17.2058