A model for measurement error for gene expression arrays

We introduce a model for measurement error in gene expression arrays as a function of the expression level. This model, together with analysis methods, data transformations, and weighting, allows much more precise comparisons of gene expression, and provides guidance for analysis of background, dete...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of computational biology 2001, Vol.8 (6), p.557-569
Hauptverfasser:	Rocke, D M, Durbin, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational Biology Confidence Intervals Data Interpretation, Statistical Gene Expression Profiling - statistics & numerical data Models, Statistical Multivariate Analysis Oligonucleotide Array Sequence Analysis - statistics & numerical data
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We introduce a model for measurement error in gene expression arrays as a function of the expression level. This model, together with analysis methods, data transformations, and weighting, allows much more precise comparisons of gene expression, and provides guidance for analysis of background, determination of confidence intervals, and preprocessing data for multivariate analysis.
ISSN:	1066-5277
DOI:	10.1089/106652701753307485