Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices

We studied the roles of mGlu2/3 receptors (mGlu2/3) in glutamatergic transmission at corticostriatal synapses in mice brain slices. Perfusion of the selective mGlu2/3 agonists LY354740 and L-CCG1 caused the long term depression (LTD) of evoked synaptic responses. Photonic and electronic microscopy s...

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Veröffentlicht in:	Neuroscience letters 2001-12, Vol.316 (3), p.178-182
Hauptverfasser:	Kahn, Laetitia, Alonso, Gérard, Robbe, David, Bockaert, Joël, Manzoni, Olivier J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Antagonists - pharmacology Animals Biological and medical sciences Central nervous system Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - ultrastructure Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dendrites - drug effects Dendrites - metabolism Dendrites - ultrastructure Dopamine Antagonists - pharmacology Electrophysiology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology Glutamate Glutamic Acid - metabolism Long term depression Male MAP Kinase Kinase 1 Membrane Potentials - drug effects Membrane Potentials - physiology Metabotropic glutamate Mice Mice, Inbred C57BL Microscopy, Electron Mitogen-activated protein kinase Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Neostriatum - drug effects Neostriatum - metabolism Neostriatum - ultrastructure Neural Inhibition - drug effects Neural Inhibition - physiology Neural Pathways - drug effects Neural Pathways - metabolism Neural Pathways - ultrastructure Neuroglia - drug effects Neuroglia - metabolism Neuroglia - ultrastructure Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Presynaptic inhibition Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - metabolism Striatum Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs
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Zusammenfassung:	We studied the roles of mGlu2/3 receptors (mGlu2/3) in glutamatergic transmission at corticostriatal synapses in mice brain slices. Perfusion of the selective mGlu2/3 agonists LY354740 and L-CCG1 caused the long term depression (LTD) of evoked synaptic responses. Photonic and electronic microscopy showed mGlu2/3 on axonal fibers and glial processes but not on striatal dendrites. mGlu2/3-LTD was independent of synaptic activity and insensitive to specific antagonists of dopamine D1, D2, GABA B, N-methyl- d-aspartate or adenosine A1 receptors. Manipulation of the cAMP/protein kinase A cascade had no effect on the mGlu2/3-LTD. In contrast, MEK1-2 inhibitors reduced both mGlu2/3 initial depression and LTD suggesting the involvement of the mitogen activated kinase pathway in mGlu2/3-LTD.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(01)02397-7