Glycosyltransferase structure and mechanism

Glycosyltransferase structure and mechanism

The high-resolution X-ray crystal structures of a new form of bacteriophage T4 β-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine β-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved. These glycosyltransferase structures have provi...

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Veröffentlicht in:Current Opinion in Structural Biology 2000-10, Vol.10 (5), p.510-517
Hauptverfasser: Ünligil, Uluğ M, Rini, James M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites
Catalytic Domain
Crystallography, X-Ray
Glycosyltransferases - chemistry
Glycosyltransferases - metabolism
Structure-Activity Relationship
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Zusammenfassung:The high-resolution X-ray crystal structures of a new form of bacteriophage T4 β-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine β-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved. These glycosyltransferase structures have provided the first detailed view of the structural basis of catalysis, as well as new insight into glycosyltransferase classification.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00124-X