The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review

Bioactivation of quinone-containing anticancer agents has been studied extensively within the context of the chemistry and structure of the individual quinones which may result in various mechanisms of bioactivation and activity. In this review we focus on the two electron enzymatic reduction/activa...

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Veröffentlicht in:	Free radical biology & medicine 2000-08, Vol.29 (3), p.263-275
1. Verfasser:	Gutierrez, Peter L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Animals Anthraquinones Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Diaziquone DT-Diaphorase Enzyme Induction Free radicals Free Radicals - metabolism Humans Indoloquinone E09 Infant Menadione Mitomycin C NAD(P)H Dehydrogenase (Quinone) - metabolism Napthazarin Oxidation-Reduction Quinones - analysis Quinones - metabolism Tumor Cells, Cultured
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