GILBERT SYNDROME ASSOCIATED WITH β-THALASSEMIA
The authors investigated whether the considerable variability in serum bilirubin levels (STB) found in transfusion-dependent g -thalassemia, g -thal intermedia, and heterozygous g -thalassemia individuals could be related to the coexistence of Gilbert syndrome (GS). The promo...
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Veröffentlicht in: | Pediatric hematology and oncology 2001, Vol.18 (8), p.477-484 |
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Sprache: | eng |
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Zusammenfassung: | The authors investigated whether the considerable variability in serum bilirubin levels (STB) found in transfusion-dependent g -thalassemia, g -thal intermedia, and heterozygous g -thalassemia individuals could be related to the coexistence of Gilbert syndrome (GS). The promoter region [A(TA) n TAA] of the bilirubin UDP-glucuronosyltransferase gene (UGT1A1) was analyzed in a total of 128 g -thalassemia individuals (108 transfusion-dependent g -thal patients, 20 very mild g -thal intermedia) and in 33 g -thal heterozygotes. The control group consisted of 70 healthy children with no history of anemia. The frequency of GS genotype (TA) 7 /(TA) 7 did not differ significantly between the groups studied. A significant difference was observed between serum bilirubin levels (STB) and GS genotypes (TA) 7 /(TA) 7 and (TA) 6 /(TA) 7 and also between (TA) 7 /(TA) 7 and (TA) 6 /(TA) 6 for all groups examined. These results confirm that the (TA) 7 /(TA) 7 GS genotype is one of the factors accounting for the hyperbilirubinemia observed in g -thalassemia major, intermedia, and heterozygous individuals. |
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ISSN: | 0888-0018 1521-0669 |
DOI: | 10.1080/088800101753328439 |