Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates

Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the no...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2001-09, Vol.132 (3), p.918-920
Hauptverfasser:	Dyuizen, I V, Motavkin, P A, Shorin, V V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Brain - drug effects Brain - metabolism Cell Nucleus - enzymology Cell Nucleus - metabolism Heroin - metabolism Heroin - pharmacology NADPH Dehydrogenase - metabolism Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Neurons - metabolism Nitric Oxide - metabolism Raphe Nuclei - enzymology Raphe Nuclei - metabolism Rats
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Zusammenfassung:	Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1013151625135