Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta

Cyclic pamidronate infusion improves bone mineralisation and reduces fracture incidence in osteogenesis imperfecta

A prospective open study was performed to determine the efficacy and safety of pamidronate in improving bone mineralisation and reducing fracture incidence in osteogenesis imperfecta (OI). Intravenous pamidronate was administered at 1.5 mg/kg bi-monthly to six children with OI, over 12-23 months. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of pediatrics 2001-11, Vol.160 (11), p.641-644
Hauptverfasser: Lee, Y S, Low, S L, Lim, L A, Loke, K Y
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Alkaline Phosphatase - blood
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Bone and Bones - injuries
Bone Density - drug effects
Calcification, Physiologic - drug effects
Child
Child, Preschool
Collagen - urine
Collagen Type I
Diphosphonates - administration & dosage
Diphosphonates - therapeutic use
Female
Fractures, Bone - prevention & control
Humans
Infusions, Intravenous
Male
Osteogenesis Imperfecta - blood
Osteogenesis Imperfecta - drug therapy
Osteogenesis Imperfecta - urine
Pamidronate
Peptides - urine
Pilot Projects
Prospective Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A prospective open study was performed to determine the efficacy and safety of pamidronate in improving bone mineralisation and reducing fracture incidence in osteogenesis imperfecta (OI). Intravenous pamidronate was administered at 1.5 mg/kg bi-monthly to six children with OI, over 12-23 months. The number of fractures decreased from median of 3 (range 1-12) to 0 fractures/year (range 0-4) (P
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310100844