Human prolactin (hPRL) antagonists inhibit hPRL-activated signaling pathways involved in breast cancer cell proliferation

The involvement of human prolactin (hPRL) in breast cancer has been recently reconsidered based on its autocrine/paracrine proliferative effect described in human mammary tumor epithelial cells. Therefore, there is growing interest in the development of potent hPRL antagonists that may inhibit this...

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Veröffentlicht in:	Oncogene 2000-09, Vol.19 (41), p.4695-4705
Hauptverfasser:	LLOVERA, Marta, PICHARD, Caroline, BERNICHTEIN, Sophie, JEAY, Sébastien, TOURAINE, Philippe, KELLY, Paul A, GOFFIN, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autocrine Communication - drug effects Autocrine signalling Binding, Competitive Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell cycle Cell Cycle - drug effects Cell Division - drug effects Cell growth Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Dimerization DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Epithelial cells Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - drug effects Growth factors Hormone Antagonists - metabolism Hormone Antagonists - pharmacology Humans Jak kinase Janus Kinase 2 Kinases Ligands Mammary gland MAP kinase MAP Kinase Signaling System - drug effects Milk Proteins Molecular and cellular biology Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - pathology Paracrine signalling Prolactin Prolactin - antagonists & inhibitors Prolactin - metabolism Prolactin - pharmacology Prolactin - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Receptors, Prolactin - agonists Receptors, Prolactin - antagonists & inhibitors Receptors, Prolactin - chemistry Receptors, Prolactin - metabolism Recombinant Fusion Proteins - metabolism Signal transduction Stat proteins STAT1 Transcription Factor STAT3 Transcription Factor STAT5 Transcription Factor Trans-Activators - antagonists & inhibitors Trans-Activators - metabolism Transcription Tumor cell lines Tumor Cells, Cultured - drug effects
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