Taraxastane-type triterpenoids from Saussurea petrovii

Two taraxastane triterpenoids, i.e. taraxast-20-ene-3β,30-diol ( 1) and 20α,21α-epoxy-taraxastane-3β,22α-diol ( 2), as well as four known triterpenes taraxast-20(30)ene-3β,21α-diol ( 3), taraxast-20(30)-ene-3β-ol ( 4), taraxast-20-ene-3β-ol ( 5) and taraxastane-3β,20α-diol ( 6) were isolated from the Chinese medicinal plant Saussurea petrovii. Their structures were elucidated by spectroscopic methods. These compounds, especially 1 and 2, exhibit significant antitumor and antibacterial activity. Taraxanst-20-ene-3β,30-diol ( 1) and 20α,21α-epoxy-taraxanstane-3β,22α-diol ( 2) were isolated from the Chinese medicinal plant Saussurea petrovii, and were found to have antitumor and antibacterial activities.