Pharmacokinetics of nelfinavir in human immunodeficiency virus-infected infants

BACKGROUND.Nelfinavir dosed at ∼20 to 30 mg/kg three times a day (TID) in older children provides exposure similar to 750 mg TID in adults. However, the pharmacokinetics (PK) of nelfinavir in infants who are

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Bibliographische Detailangaben
Veröffentlicht in:	The Pediatric infectious disease journal 2001-08, Vol.20 (8), p.746-751
Hauptverfasser:	CAPPARELLI, EDMUND V, SULLIVAN, JOHN L, MOFENSON, LYNNE, SMITH, ELIZABETH, GRAHAM, BOBBIE, BRITTO, PAULA, BECKER, MARK I, HOLLAND, DIANNE, CONNOR, JAMES D, LUZURIAGA, KATHERINE
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Child, Preschool Drug Therapy, Combination HIV Infections - drug therapy HIV Infections - virology HIV-1 - physiology Humans Infant Infant, Newborn Medical sciences Nelfinavir - pharmacokinetics Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood
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Beschreibung
Zusammenfassung:	BACKGROUND.Nelfinavir dosed at ∼20 to 30 mg/kg three times a day (TID) in older children provides exposure similar to 750 mg TID in adults. However, the pharmacokinetics (PK) of nelfinavir in infants who are
ISSN:	0891-3668 1532-0987
DOI:	10.1097/00006454-200108000-00006