The Fuss about Mus81

The Fuss about Mus81

Endonucleolytic cleavage of Holliday junctions is important in recombination and replication. Mus81 proteins in yeasts and humans appear to have many, but not all, of the expected properties of eukaryotic Holliday junction resolvases, with intriguing connections to DNA replication checkpoints.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell 2001-11, Vol.107 (5), p.551-554
Hauptverfasser: Haber, James E, Heyer, Wolf-Dietrich
Format: Artikel
Sprache:eng
Schlagworte:
Animals
DNA - genetics
DNA - metabolism
DNA Damage
DNA Repair
DNA Replication
DNA, Fungal - genetics
DNA, Fungal - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Endodeoxyribonucleases - metabolism
Endonucleases
Flap Endonucleases
Fungal Proteins - genetics
Fungal Proteins - metabolism
Holliday Junction Resolvases
Humans
Recombination, Genetic
Saccharomyces cerevisiae Proteins
Trans-Activators - genetics
Trans-Activators - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Endonucleolytic cleavage of Holliday junctions is important in recombination and replication. Mus81 proteins in yeasts and humans appear to have many, but not all, of the expected properties of eukaryotic Holliday junction resolvases, with intriguing connections to DNA replication checkpoints.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(01)00593-1