Hypotensive Effect of Chemical Constituents from Aloe barbadensis

Abstract Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from ALOE BARBADENSIS have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the...

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Veröffentlicht in:	Planta medica 2001-11, Vol.67 (8), p.757-760
Hauptverfasser:	Saleem, Rubeena, Faizi, Shaheen, Shaheen Siddiqui, Bina, Ahmed, Muhammad, Hussain, Syed Ahmed, Qazi, Aamer, Dar, Ahsana, Ahmad, Syed Iqbal, Qazi, Mahmood Hussain, Akhtar, Shamim, Hasnain, Syed Nazrul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aloe - chemistry Animals Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - therapeutic use Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Pressure - drug effects Dose-Response Relationship, Drug Emodin - analogs & derivatives Emodin - chemistry Emodin - isolation & purification Emodin - pharmacology Emodin - therapeutic use General pharmacology Glucosides - chemistry Glucosides - isolation & purification Glucosides - therapeutic use Hypertension - drug therapy Letter Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Leaves - chemistry Plant Preparations - therapeutic use Plant Roots - chemistry Rats
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Zusammenfassung:	Abstract Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from ALOE BARBADENSIS have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2001-18348