Dual effect of glucocorticoids on apoptosis of human autoreactive and foreign antigen-specific T cells

The efficacy of glucocorticoids in the treatment of multiple sclerosis may involve the induction of T cell apoptosis. Here, we report that glucocorticoids have two different effects on the vulnerability of human antigen-specific T cells: (i) steroids induce T cell apoptosis in a CD95-independent, bu...

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Veröffentlicht in:Journal of neuroimmunology 2000-10, Vol.110 (1), p.214-222
Hauptverfasser: Zipp, Frauke, Wendling, Uwe, Beyer, Martin, Grieger, Ulrike, Waiczies, Sonia, Wagenknecht, Bettina, Haas, Judith, Weller, Michael
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Sprache:eng
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Zusammenfassung:The efficacy of glucocorticoids in the treatment of multiple sclerosis may involve the induction of T cell apoptosis. Here, we report that glucocorticoids have two different effects on the vulnerability of human antigen-specific T cells: (i) steroids induce T cell apoptosis in a CD95-independent, but caspase-dependent manner; (ii) steroids protect T cells from CD95-mediated apoptosis which, however, is also caspase-dependent. An increase in BCL-2 expression is observed upon incubation with steroids. Thus, inhibition of CD95-mediated T cell apoptosis may be an undesirable side-effect resulting in survival of activated T cells and the maintenance of pathogenic immune responses might explain the lack of long-term glucocorticoid therapy.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(00)00337-4