Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study
We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene ( FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants ( n=1930). In men, the T54 allele was associated with significantly higher LDL-...
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| Veröffentlicht in: | Atherosclerosis 2001-12, Vol.159 (2), p.417-424 |
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| creator | Galluzzi, Jennifer R Cupples, L.Adrienne Otvos, James D Wilson, Peter W.F Schaefer, Ernst J Ordovas, Jose M |
| description | We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene (
FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants (
n=1930). In men, the T54 allele was associated with significantly higher LDL-cholesterol (3.47±0.83 vs 3.36±0.83 mmol/l;
P |
| doi_str_mv | 10.1016/S0021-9150(01)00517-2 |
| format | Article |
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FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants (
n=1930). In men, the T54 allele was associated with significantly higher LDL-cholesterol (3.47±0.83 vs 3.36±0.83 mmol/l;
P<0.047), and ApoB (1.04±0.23 vs 1.01±0.24 g/l;
P<0.020) after adjustment for familial relationship, age, BMI, smoking, alcohol intake and the use of beta-blockers compared with the A54 allele. This relationship with ApoB continued to be significant after adjustment for
APOE genotype (
P<0.034). In women, the T54 allele was associated with significantly higher total-cholesterol (5.32±1.01 vs 5.17±0.98 mmol/l;
P<0.049) and LDL-cholesterol (3.31±0.93 vs 3.18±0.85 mmol/l;
P<0.023) after adjustment for covariates and menopausal status, estrogen therapy and
APOE genotype. In men, the T54 allele was associated with significantly higher levels of small VLDL and lower levels of large HDL. Moreover, there was no significant relationship between
FABP2 alleles and lipoprotein diameter or the prevalence of coronary heart disease in both genders. Our data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(01)00517-2</identifier><identifier>PMID: 11730822</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Age Distribution ; Aged ; Alleles ; Apolipoproteins - blood ; Biological and medical sciences ; Cardiology. Vascular system ; Carrier Proteins - genetics ; Cholesterol ; Cohort Studies ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; Coronary heart disease ; FABP2 ; Fatty Acid-Binding Protein 7 ; Fatty Acid-Binding Proteins ; Fatty Acids - metabolism ; Female ; Framingham ; Genetic Predisposition to Disease - epidemiology ; Genetic Variation ; Heart ; Humans ; Incidence ; Lipids - blood ; Lipoproteins - blood ; Male ; Medical sciences ; Middle Aged ; Neoplasm Proteins ; Polymorphism ; Polymorphism, Genetic ; Probability ; Prospective Studies ; Risk Factors ; Sex Distribution ; Tumor Suppressor Proteins</subject><ispartof>Atherosclerosis, 2001-12, Vol.159 (2), p.417-424</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f87cc5e426eccb3358bb5cef46fbf6fe06e25f37f64bb75a423d8801b8adc6113</citedby><cites>FETCH-LOGICAL-c391t-f87cc5e426eccb3358bb5cef46fbf6fe06e25f37f64bb75a423d8801b8adc6113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915001005172$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14118292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11730822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galluzzi, Jennifer R</creatorcontrib><creatorcontrib>Cupples, L.Adrienne</creatorcontrib><creatorcontrib>Otvos, James D</creatorcontrib><creatorcontrib>Wilson, Peter W.F</creatorcontrib><creatorcontrib>Schaefer, Ernst J</creatorcontrib><creatorcontrib>Ordovas, Jose M</creatorcontrib><title>Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene (
FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants (
n=1930). In men, the T54 allele was associated with significantly higher LDL-cholesterol (3.47±0.83 vs 3.36±0.83 mmol/l;
P<0.047), and ApoB (1.04±0.23 vs 1.01±0.24 g/l;
P<0.020) after adjustment for familial relationship, age, BMI, smoking, alcohol intake and the use of beta-blockers compared with the A54 allele. This relationship with ApoB continued to be significant after adjustment for
APOE genotype (
P<0.034). In women, the T54 allele was associated with significantly higher total-cholesterol (5.32±1.01 vs 5.17±0.98 mmol/l;
P<0.049) and LDL-cholesterol (3.31±0.93 vs 3.18±0.85 mmol/l;
P<0.023) after adjustment for covariates and menopausal status, estrogen therapy and
APOE genotype. In men, the T54 allele was associated with significantly higher levels of small VLDL and lower levels of large HDL. Moreover, there was no significant relationship between
FABP2 alleles and lipoprotein diameter or the prevalence of coronary heart disease in both genders. Our data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion.</description><subject>Age Distribution</subject><subject>Aged</subject><subject>Alleles</subject><subject>Apolipoproteins - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Carrier Proteins - genetics</subject><subject>Cholesterol</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary heart disease</subject><subject>FABP2</subject><subject>Fatty Acid-Binding Protein 7</subject><subject>Fatty Acid-Binding Proteins</subject><subject>Fatty Acids - metabolism</subject><subject>Female</subject><subject>Framingham</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Variation</subject><subject>Heart</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Tumor Suppressor Proteins</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EokPhE0DegGAR6uc4iWeFRhUFpEpddFhbjmMzDyV2sD1F8yH8L87MiC5ZWbLPvb7vXUJeA_sIDNqre8Y4VGto2HsGHxhroKv4E7IC2a0rEFI8Jat_yAV5kdJPxpjoQD4nFwBdzSTnK_Jnk1IwqDMGT4OjeWfp5mrbCDqH8TCFOO8wTRT98QV9timj1yN1OucD1QYH2qMf0P-gcwzZFvI35h190PHkmhbxPOo0aTrijMPxYlvcbqKeim6nJ3rnXJrjYnKf98PhJXnm9Jjsq_N5Sb7ffN5ef61u7758u97cVqZeQ66c7IxprOCtNaav60b2fWOsE63rXessay1vXN25VvR912jB60FKBr3Ug2kB6kvy7uRbov_al9HUhMnYcdTehn1SHa-hFbIuYHMCTQwpRetUSTvpeFDA1NKHOvahlmUrBurYh-JF9-b8wb6f7PCoOhdQgLdnQCejRxe1N5geOQEg-XrhPp04W9bxgDaqZNB6YweM1mQ1BPxPlL_prqoB</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Galluzzi, Jennifer R</creator><creator>Cupples, L.Adrienne</creator><creator>Otvos, James D</creator><creator>Wilson, Peter W.F</creator><creator>Schaefer, Ernst J</creator><creator>Ordovas, Jose M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study</title><author>Galluzzi, Jennifer R ; Cupples, L.Adrienne ; Otvos, James D ; Wilson, Peter W.F ; Schaefer, Ernst J ; Ordovas, Jose M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f87cc5e426eccb3358bb5cef46fbf6fe06e25f37f64bb75a423d8801b8adc6113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Distribution</topic><topic>Aged</topic><topic>Alleles</topic><topic>Apolipoproteins - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Carrier Proteins - genetics</topic><topic>Cholesterol</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary heart disease</topic><topic>FABP2</topic><topic>Fatty Acid-Binding Protein 7</topic><topic>Fatty Acid-Binding Proteins</topic><topic>Fatty Acids - metabolism</topic><topic>Female</topic><topic>Framingham</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Variation</topic><topic>Heart</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Probability</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Tumor Suppressor Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galluzzi, Jennifer R</creatorcontrib><creatorcontrib>Cupples, L.Adrienne</creatorcontrib><creatorcontrib>Otvos, James D</creatorcontrib><creatorcontrib>Wilson, Peter W.F</creatorcontrib><creatorcontrib>Schaefer, Ernst J</creatorcontrib><creatorcontrib>Ordovas, Jose M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galluzzi, Jennifer R</au><au>Cupples, L.Adrienne</au><au>Otvos, James D</au><au>Wilson, Peter W.F</au><au>Schaefer, Ernst J</au><au>Ordovas, Jose M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>159</volume><issue>2</issue><spage>417</spage><epage>424</epage><pages>417-424</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene (
FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants (
n=1930). In men, the T54 allele was associated with significantly higher LDL-cholesterol (3.47±0.83 vs 3.36±0.83 mmol/l;
P<0.047), and ApoB (1.04±0.23 vs 1.01±0.24 g/l;
P<0.020) after adjustment for familial relationship, age, BMI, smoking, alcohol intake and the use of beta-blockers compared with the A54 allele. This relationship with ApoB continued to be significant after adjustment for
APOE genotype (
P<0.034). In women, the T54 allele was associated with significantly higher total-cholesterol (5.32±1.01 vs 5.17±0.98 mmol/l;
P<0.049) and LDL-cholesterol (3.31±0.93 vs 3.18±0.85 mmol/l;
P<0.023) after adjustment for covariates and menopausal status, estrogen therapy and
APOE genotype. In men, the T54 allele was associated with significantly higher levels of small VLDL and lower levels of large HDL. Moreover, there was no significant relationship between
FABP2 alleles and lipoprotein diameter or the prevalence of coronary heart disease in both genders. Our data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>11730822</pmid><doi>10.1016/S0021-9150(01)00517-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Atherosclerosis, 2001-12, Vol.159 (2), p.417-424 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Distribution Aged Alleles Apolipoproteins - blood Biological and medical sciences Cardiology. Vascular system Carrier Proteins - genetics Cholesterol Cohort Studies Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary heart disease FABP2 Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins Fatty Acids - metabolism Female Framingham Genetic Predisposition to Disease - epidemiology Genetic Variation Heart Humans Incidence Lipids - blood Lipoproteins - blood Male Medical sciences Middle Aged Neoplasm Proteins Polymorphism Polymorphism, Genetic Probability Prospective Studies Risk Factors Sex Distribution Tumor Suppressor Proteins |
| title | Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study |
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