Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study

We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene ( FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants ( n=1930). In men, the T54 allele was associated with significantly higher LDL-...

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Veröffentlicht in:	Atherosclerosis 2001-12, Vol.159 (2), p.417-424
Hauptverfasser:	Galluzzi, Jennifer R, Cupples, L.Adrienne, Otvos, James D, Wilson, Peter W.F, Schaefer, Ernst J, Ordovas, Jose M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Distribution Aged Alleles Apolipoproteins - blood Biological and medical sciences Cardiology. Vascular system Carrier Proteins - genetics Cholesterol Cohort Studies Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary heart disease FABP2 Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins Fatty Acids - metabolism Female Framingham Genetic Predisposition to Disease - epidemiology Genetic Variation Heart Humans Incidence Lipids - blood Lipoproteins - blood Male Medical sciences Middle Aged Neoplasm Proteins Polymorphism Polymorphism, Genetic Probability Prospective Studies Risk Factors Sex Distribution Tumor Suppressor Proteins
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Zusammenfassung:	We investigated the potential role of the genetic variation at the intestinal fatty acid binding protein gene ( FABP2) in influencing lipid levels in a representative sample of the Framingham Offspring Study participants ( n=1930). In men, the T54 allele was associated with significantly higher LDL-cholesterol (3.47±0.83 vs 3.36±0.83 mmol/l; P
ISSN:	0021-9150 1879-1484
DOI:	10.1016/S0021-9150(01)00517-2