Endogenous heparin activity deficiency: the ‘Missing Link’ in atherogenesis?

This paper reviews published studies since 1995 dealing with many atherogenic mechanisms where exogenous heparin was beneficial. In these areas endogenous heparin deficiency is likely to be harmful. Mechanisms included inflammatory factors, lower endogenous plasma heparin levels, lipoprotein lipase,...

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Veröffentlicht in:	Atherosclerosis 2001-12, Vol.159 (2), p.253-260
1. Verfasser:	Engelberg, Hyman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - etiology Arteriosclerosis - physiopathology Atherogenesis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chemokines - deficiency Chemokines - metabolism Endogenous Heparin Deficiency Haplorhini Heparin - deficiency Heparin - metabolism Humans Lipoprotein Lipase - deficiency Lipoprotein Lipase - metabolism Medical sciences Peptidyl-Dipeptidase A - deficiency Peptidyl-Dipeptidase A - metabolism Phospholipases A - deficiency Phospholipases A - metabolism Prognosis Risk Factors Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	This paper reviews published studies since 1995 dealing with many atherogenic mechanisms where exogenous heparin was beneficial. In these areas endogenous heparin deficiency is likely to be harmful. Mechanisms included inflammatory factors, lower endogenous plasma heparin levels, lipoprotein lipase, chemokines, APOE e4, lipoprotein(a), among others. Demonstrated reduction of heparan sulfate proteoglycans (HSPG) and of endogenous plasma heparin was reviewed.
ISSN:	0021-9150 1879-1484
DOI:	10.1016/S0021-9150(01)00650-5