Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men

In subjects with normal vascular function, 80 mg of atorvastatin improved endothelial function within 24 hours, before serum cholesterol and high-sensitivity C-reactive protein was decreased after 2 days of treatment. Withdrawal of statin therapy after 30 days acutely impaired vascular function inde...

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Veröffentlicht in:	The American journal of cardiology 2001-12, Vol.88 (11), p.1306-1307
Hauptverfasser:	Laufs, Ulrich, Wassmann, Sven, Hilgers, Stefan, Ribaudo, Nicole, Böhm, Michael, Nickenig, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atorvastatin Blood Flow Velocity C-Reactive Protein - analysis Cardiology Cholesterol Cholesterol - blood Drug therapy Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Forearm - blood supply Heptanoic Acids - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Men Nitroglycerin - pharmacology Plethysmography Pyrroles - pharmacology Reference Values Vasodilation - drug effects
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Zusammenfassung:	In subjects with normal vascular function, 80 mg of atorvastatin improved endothelial function within 24 hours, before serum cholesterol and high-sensitivity C-reactive protein was decreased after 2 days of treatment. Withdrawal of statin therapy after 30 days acutely impaired vascular function independent of cholesterol levels.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(01)02095-1