Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing reg...

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Veröffentlicht in:	Nature medicine 2000-10, Vol.6 (10), p.1160-1166
Hauptverfasser:	Wei, Yu-quan, Wang, Qing-ru, Zhao, Xia, Yang, Li, Tian, Ling, Lu, You, Kang, Bin, Lu, Chong-jiu, Huang, Mei-juan, Lou, Yan-yan, Xiao, Fei, He, Qiu-ming, Shu, Jing-mei, Xie, Xing-jiang, Mao, Yun-qiu, Lei, Shong, Luo, Feng, Zhou, Li-qun, Liu, Chong-en, Zhou, Hao, Jiang, Yu, Peng, Feng, Yuan, Liang-ping, Li, Qiu, Wu, Yang, Liu, Ji-yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiogenesis Animals Antigens, CD - immunology Autoantibodies - immunology Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Cancer Vaccines - pharmacology Care and treatment Cattle CD4-Positive T-Lymphocytes - immunology Cells, Cultured Cross Reactions Drug dosages Endothelium Endothelium - cytology Endothelium - immunology Endothelium, Vascular - cytology Endothelium, Vascular - immunology Health aspects Humans Immunoglobulins Immunotherapy Immunotherapy - methods Infectious Diseases Integrin alphaV Lymphocytes Metabolic Diseases Mice Molecular Medicine Molecular Sequence Data Neoplasms, Experimental - therapy Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - immunology Neurosciences Peptides - immunology Prevention Proteins Receptor Protein-Tyrosine Kinases - immunology Receptors, Growth Factor - immunology Receptors, Vascular Endothelial Growth Factor Tumors Vaccines
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