Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing reg...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature medicine 2000-10, Vol.6 (10), p.1160-1166
Hauptverfasser: Wei, Yu-quan, Wang, Qing-ru, Zhao, Xia, Yang, Li, Tian, Ling, Lu, You, Kang, Bin, Lu, Chong-jiu, Huang, Mei-juan, Lou, Yan-yan, Xiao, Fei, He, Qiu-ming, Shu, Jing-mei, Xie, Xing-jiang, Mao, Yun-qiu, Lei, Shong, Luo, Feng, Zhou, Li-qun, Liu, Chong-en, Zhou, Hao, Jiang, Yu, Peng, Feng, Yuan, Liang-ping, Li, Qiu, Wu, Yang, Liu, Ji-yan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.
ISSN:1078-8956
1546-170X
DOI:10.1038/80506