Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing reg...
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| Veröffentlicht in: | Nature medicine 2000-10, Vol.6 (10), p.1160-1166 |
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| creator | Wei, Yu-quan Wang, Qing-ru Zhao, Xia Yang, Li Tian, Ling Lu, You Kang, Bin Lu, Chong-jiu Huang, Mei-juan Lou, Yan-yan Xiao, Fei He, Qiu-ming Shu, Jing-mei Xie, Xing-jiang Mao, Yun-qiu Lei, Shong Luo, Feng Zhou, Li-qun Liu, Chong-en Zhou, Hao Jiang, Yu Peng, Feng Yuan, Liang-ping Li, Qiu Wu, Yang Liu, Ji-yan |
| description | The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction. |
| doi_str_mv | 10.1038/80506 |
| format | Article |
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Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/80506</identifier><identifier>PMID: 11017149</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Amino Acid Sequence ; Angiogenesis ; Animals ; Antigens, CD - immunology ; Autoantibodies - immunology ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Cancer Vaccines - pharmacology ; Care and treatment ; Cattle ; CD4-Positive T-Lymphocytes - immunology ; Cells, Cultured ; Cross Reactions ; Drug dosages ; Endothelium ; Endothelium - cytology ; Endothelium - immunology ; Endothelium, Vascular - cytology ; Endothelium, Vascular - immunology ; Health aspects ; Humans ; Immunoglobulins ; Immunotherapy ; Immunotherapy - methods ; Infectious Diseases ; Integrin alphaV ; Lymphocytes ; Metabolic Diseases ; Mice ; Molecular Medicine ; Molecular Sequence Data ; Neoplasms, Experimental - therapy ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Pathologic - immunology ; Neurosciences ; Peptides - immunology ; Prevention ; Proteins ; Receptor Protein-Tyrosine Kinases - immunology ; Receptors, Growth Factor - immunology ; Receptors, Vascular Endothelial Growth Factor ; Tumors ; Vaccines</subject><ispartof>Nature medicine, 2000-10, Vol.6 (10), p.1160-1166</ispartof><rights>Nature America Inc. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-afdd63d3f521f3eed5cce5b8664d2317554285147ec2a0bb4ae7a55407b607883</citedby><cites>FETCH-LOGICAL-c564t-afdd63d3f521f3eed5cce5b8664d2317554285147ec2a0bb4ae7a55407b607883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11017149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Yu-quan</creatorcontrib><creatorcontrib>Wang, Qing-ru</creatorcontrib><creatorcontrib>Zhao, Xia</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Tian, Ling</creatorcontrib><creatorcontrib>Lu, You</creatorcontrib><creatorcontrib>Kang, Bin</creatorcontrib><creatorcontrib>Lu, Chong-jiu</creatorcontrib><creatorcontrib>Huang, Mei-juan</creatorcontrib><creatorcontrib>Lou, Yan-yan</creatorcontrib><creatorcontrib>Xiao, Fei</creatorcontrib><creatorcontrib>He, Qiu-ming</creatorcontrib><creatorcontrib>Shu, Jing-mei</creatorcontrib><creatorcontrib>Xie, Xing-jiang</creatorcontrib><creatorcontrib>Mao, Yun-qiu</creatorcontrib><creatorcontrib>Lei, Shong</creatorcontrib><creatorcontrib>Luo, Feng</creatorcontrib><creatorcontrib>Zhou, Li-qun</creatorcontrib><creatorcontrib>Liu, Chong-en</creatorcontrib><creatorcontrib>Zhou, Hao</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Peng, Feng</creatorcontrib><creatorcontrib>Yuan, Liang-ping</creatorcontrib><creatorcontrib>Li, Qiu</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Liu, Ji-yan</creatorcontrib><title>Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.</description><subject>Amino Acid Sequence</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Antigens, CD - immunology</subject><subject>Autoantibodies - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer therapies</subject><subject>Cancer Vaccines - pharmacology</subject><subject>Care and treatment</subject><subject>Cattle</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cells, Cultured</subject><subject>Cross Reactions</subject><subject>Drug dosages</subject><subject>Endothelium</subject><subject>Endothelium - cytology</subject><subject>Endothelium - immunology</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Infectious Diseases</subject><subject>Integrin alphaV</subject><subject>Lymphocytes</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Molecular Medicine</subject><subject>Molecular Sequence Data</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - immunology</subject><subject>Neurosciences</subject><subject>Peptides - immunology</subject><subject>Prevention</subject><subject>Proteins</subject><subject>Receptor Protein-Tyrosine Kinases - immunology</subject><subject>Receptors, Growth Factor - immunology</subject><subject>Receptors, Vascular Endothelial Growth Factor</subject><subject>Tumors</subject><subject>Vaccines</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0ltr2zAUAGAzNtbL-heGN1ihD-50rJv9WEq7BgqF3dibkeXjRMWWMkle239fZQnLUgobEkhIn46kw8myIyCnQGj1sSKciBfZPnAmCpDkx8s0J7IqqpqLvewghFtCCCW8fp3tARCQwOr97HI2jpN1cYFeLR9y1-dxGp0P-Z2Ji_werZujRaNztN1KDUYNucZhCLlKPf-ltDYW32SvejUEPNqMh9m3y4uv51fF9c2n2fnZdaG5YLFQfdcJ2tGel9BTxI5rjbythGBdSUFyzsqKA5OoS0XalimUKi0S2Yr0l4oeZsfruEvvfk4YYjOasHqOsuim0MiSkorW8p8QpKAMJEvw_RN46yZv0yeaMj0J6prXCRVrNFcDNsb2LnqlV5nxanAWe5OWz6BmwKGCMvnTZ3xqHY5GP3vgZOdAMhHv41xNITSzL5__395837XHf9kFqiEughumaJwNu_DDGmrvQvDYN0tvRuUfGiDNqsCa3wWW3NtNuqZ2xG6rNhW1vTGkLTtHv83n00jv1tCqOHn8E8mOkAo1BRSEPgJNF9yA</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Wei, 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| subjects | Amino Acid Sequence Angiogenesis Animals Antigens, CD - immunology Autoantibodies - immunology Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Cancer Vaccines - pharmacology Care and treatment Cattle CD4-Positive T-Lymphocytes - immunology Cells, Cultured Cross Reactions Drug dosages Endothelium Endothelium - cytology Endothelium - immunology Endothelium, Vascular - cytology Endothelium, Vascular - immunology Health aspects Humans Immunoglobulins Immunotherapy Immunotherapy - methods Infectious Diseases Integrin alphaV Lymphocytes Metabolic Diseases Mice Molecular Medicine Molecular Sequence Data Neoplasms, Experimental - therapy Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - immunology Neurosciences Peptides - immunology Prevention Proteins Receptor Protein-Tyrosine Kinases - immunology Receptors, Growth Factor - immunology Receptors, Vascular Endothelial Growth Factor Tumors Vaccines |
| title | Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine |
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