Mechanisms of amyloidogenesis

Mechanisms of amyloidogenesis

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion — that invokes oligomeric intermediates for initiation and assembly.

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Veröffentlicht in:Nature Structural Biology 2000-10, Vol.7 (10), p.824-826
1. Verfasser: Kelly, Jeffery W.
Format: Artikel
Sprache:eng
Schlagworte:
Amyloid - biosynthesis
Amyloid - metabolism
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Fungal Proteins - biosynthesis
Kinetics
Life Sciences
Membrane Biology
Models, Molecular
Molecular Probes
news-and-views
Peptide Termination Factors
Prions - biosynthesis
Protein Structure
Saccharomyces cerevisiae Proteins
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Beschreibung
Zusammenfassung:Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion — that invokes oligomeric intermediates for initiation and assembly.
ISSN:1072-8368
1545-9993
1545-9985
DOI:10.1038/82815